Prophylactic vitamin K for newborns: oral or injection?

Proceedings of the Third International Conference of the College of Medicine, Hawler Medical University

Prophylactic vitamin K for newborns: oral or injection?

Shwan Azad Hussein, Erbil Directorate of Health, Erbil, Iraq

Dlair A.K. Chalabi, Department of Pediatrics, College of Medicine, Hawler Medical University, Erbil, Iraq

Email: [email protected]

DOI: 10.15218/com.03.10

Published: 21 Jan 2019

Fulltext

Abstract

Background and objectives: Vitamin K-dependent coagulation factors are physiologically decreased after birth and may make newborns vulnerable to serious bleeding disorders. Prophylactic Parenteral Vitamin K immediately after delivery is recommended worldwide. The objective of this study was to evaluate effectiveness of oral vitamin k prophylaxis compared to intramuscular one in prevention of classical hemorrhagic disease of newborns and report any serious side effects related.

Methods: A prospective comparable study was carried out at the postnatal delivery care unit of Maternity Teaching hospital in Erbil on 100 term healthy newborn divided equally into two groups; those who received parenteral Vitamin K and others who received oral one. Prothrombin Time (PT), International N ratio (INR) and Partial thromboplastin time (PTT) were measured on day 3 to estimate effectiveness of different routes of prophylaxis.

Results: One hundred newborns tested early (54% during first hour of life) for PT, PTT and INR. Means of the tests were not significantly different between 2 groups and no serious side effects have been reported, few patients complain of irritability in the first few hours with IM route, but no significant local or systemic reactions while one patient with oral route had vomiting immediately and dose given again

Conclusion: Vitamin k prophylaxis whether oral or IM have same effect on bleeding profile during early evaluation of full-term newborn.

Keywords: Newborn, Prophylaxis, Vitamin K.

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